2024
Ziyi Wang, Hongying Zhu, Wei Xiong. Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective. Frontiers of Medicine, 2024 November https://doi.org/10.1007/s11684-024-1116-0
Jin Jin#, Chonglei Fu#, Jing Xia#, Heyi Luo#, Xianglian Wang, Si Chen, Huanhuan Mao, Kai Yuan, Lin Lu*, Wei Xiong* & Guichang Zou*. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer’s disease through potentiating the function of extrasynaptic glycine receptors. Molecular Psychiatry, 2024 October https://doi.org/10.1038/s41380-024-02789-x.
Jieping Lu#, Xin Zuo#*, Aoling Cai#, Fang Xiao, Zhenyu Xu, Rui Wang, Chenjian Miao, Chen Yang, Xingxing Zheng, Jie Wang, Xiaoling Ding*, Wei Xiong*. ACE2-expressing cerebral vascular endothelial cells and post COVID-19 patients. Alzheimer's & Dementia, 2024 October https://doi.org/10.1002/alz.14279.
Xiaolin Lian, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell Discovery, 2024 May 21;10(1):54. doi: 10.1038/s41421-024-00667-y.
Weiwei Guo, Wei Xiong*. From gut microbiota to brain: implications on binge eating disorders. Gut Microbes, 2024 Jan-Dec;16(1):2357177. doi: 10.1080/19490976.2024.2357177.
Shunchang Fang, Zhengyi Luo, Zicheng Wei, Yuxin Qin, Jieyan Zheng, Hongyang Zhang, Jianhua Jin, Jiali Li, Chenjian Miao, Shana Yang, Yonglin Li, Zirui Liang, Xiao-Dan Yu, Xiao Min Zhang, Wei Xiong, Hongying Zhu, Wen-Biao Gan, Lianyan Huang, Boxing Li,Sexually dimorphic control of affective state processing and empathic behaviors. Neuron, 2024 May 1;112(9):1498-1517.e8. doi: 10.1016/j.neuron.2024.02.001.
Qianping Zhang, Tiantian Sun, Fan Yu, Wei Liu, Jin Gao, Jinyu Chen, Hao Zheng, Jinming Liu, Chenjian Miao, Huanyi Guo, Wu Tian, Meihui Su, Yingjie Guo, Xi Liu, Yandong Pei, Zhuofei Wang, Shang Chen, Chenglong Mu, Sin Man Lam, Guanghou Shui, Zongjin Li, Zhongbo Yu, Yan Zhang, Guo Chen, Congcong Lu, Adam C. Midgley, Changhua Li, Xin Bian, Xudong Liao, Yong Wang*, Wei Xiong*, Hongying Zhu*, Yanjun Li* & Quan Chen*. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury. Nature Chemical Biology, 2024 Jul;20(7):934. doi: 10.1038/s41589-024-01566-9
2023
Sijia Fan#, Weiwei Guo#, Dan Xiao, Mengyuan Guan, Tiepeng Liao, Sufang Peng, Airong Feng, Ziyi Wang, Hao Yin, Min Li*, Jue Chen*, Wei Xiong*. Microbiota-gut-brain axis drives overeating disorders. Cell Metabolism, 35(11):2011-2027(2023). https://doi.org/10.1016/j.cmet.2023.09.005
Ziyi Wang, Hongying Zhu*, Wei Xiong*. Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clinical investigations. Science Bulletin, 68(19), 2268-2284 (2023). https://doi.org/10.1016/j.scib.2023.08.047
Tiepeng Liao, Zihao Ren, Zhaoliang Chai, Man Yuan, Chenjian Miao, Junjie Li, Qi Chen, Zhilin Li, Ziyi Wang, Lin Yi, Siyuan Ge, Wenwei Qian, Longfeng Shen, Zilei Wang, Wei Xiong*, Hongying Zhu*. A super-resolution strategy for mass spectrometry imaging via transfer learning. Nature Machine Intelligence, 5, 656–668 (2023)
Jing Xia, Dan Xiao, Heyi Luo, Jin Jin, Siyuan Ge, Xianglian Wang, Guichang Zou*, Wei Xiong*. The cannabinoid dehydroxylcannabidiol suppresses neuropathic pain by upregulating a spinal glycine receptor-mediated compensation mechanism. Journal of Biological Chemistry, 299(6): 104769 (2023)
Yiwen Hou#, Guichang Zou#, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong*. Coordinated activity of a central pathway drives associative opioid analgesic tolerance. Science Advances, 9(6) (2023)
Jie Ren, Moshi Song, Weiqi Zhang, Jian-Ping Cai, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Xiao-Chun Chen, Weimin Ci, Bi-Sen Ding, Qiurong Ding, Feng Gao, Shaorong Gao, Jing-Dong J. Han, Qi-Yang He, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Jingyi Li, Xin Li, Baohua Liu, Feng Liu, Jun-Ping Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Ruibao Ren, Weihong Song, Zhou Songyang, Liang Sun, Yi Eve Sun, Yu Sun, Mei Tian, Xiao-Li Tian, Ye Tian, Jianwei Wang, Shusen Wang, Si Wang, Wengong Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C. L. Wong, Andy Peng Xiang, Yichuan Xiao, Zhi-Xiong Xiao, Zhengwei Xie, Wei Xiong, Daichao Xu, Ze Yang, Jing Ye, Wei Yu, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Xinchao Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Zhongjun Zhou, Dahai Zhu, Weiguo Zou, Gang Pei, Guang-Hui Liu*. The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine, (2023)
Bo Liu*, Yuanyuan Zhou, Qiaofeng Wu, Yuting Fu, Xianli Zhang, Zhenkun Wang, Weiwei Yi, Hu Wang, Zhiyang Chen, Zhangfa Song, Wei Xiong, Yugang Qiu, Weifeng He*, Zhenyu Ju*. EVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosis. Cell Death & Disease, 14(71) (2023)
2022
Weiwei Guo#, Sijia Fan#, Dan Xiao, Chen He, Mengyuan Guan, Wei Xiong*. A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions. Molecular Psychiatry, 27: 4881-4892 (2022)
Guichang Zou#, Jing Xia#, Heyi Luo, Dan Xiao, Jin Jin, Chenjian Miao, Xin Zuo, Qianqian Gao, Zhi Zhang, Tian Xue, Yezi You, Ye Zhang, Li Zhang, Wei Xiong*. Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism, 4: 1138–1149 (2022)
Ziyi Wang, Fei Sun, Wei Xiong*. Fat shapes fate: unlock the destiny of a cell with single-cell metabolomics. Life Medicine, 1(3) 261–263 (2022)
Hao-Di Tang#, Wan-Ying Dong#, Rui Hu#, Ji-Ye Huang, Zhao-Huan Huang, Wei Xiong, Tian Xue, Ji Liu*, Jun-Ma Yu*, Xia Zhu*, Zhi Zhang*. A neural circuit for the suppression of feeding under persistent pain. Nature Metabolism, 4, 1746–1755 (2022)
Jiaxi Hu#, Yiming Shi#, Jiaming Zhang, Xinfeng Huang, Qian Wang, Hang Zhao, Jiawei Shen, Zhiping Chen, Wei Song, Ping Zheng, Shulu Zhan, Yanping Sun, Pengfei Cai, Kai An, Changjie Ouyang, Baizhen Zhao, Qixin Zhou, Lin Xu, Wei Xiong, Zhi Zhang, Jianjun Meng, Jutao Chen, Yuqian Ma, Huan Zhao, Mei Zhang, Kun Qu, Ji Hu, Minhua Luo, Fuqiang Xu, Xiaowei Chen, Ying Xiong, Jin Bao*, Tian Xue*. Melanopsin retinal ganglion cells mediate light-promoted brain development. Cell, 185(17): 3124-3137 (2022)
2021
Weiwei Guo#, Sijia Fan#, Dan Xiao, Hui Dong, Guangwei Xu, Zhikun Wan, Yuqian Ma, Zhen Wang, Tian Xue, Yifeng Zhou, Yulong Li, Wei Xiong*. A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications, 12, 6403 (2021)
Hongying Zhu#, Qianqian Li#, Tiepeng Liao#, Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang*, Wei Xiong*. Metabolomic profiling of single enlarged lysosomes. Nature Methods, 18(7), 788-798 (2021). (封面文章)
Yujun Guo#, Guichang Zou#, Keke Qi, Jin Jin, Lei Yao, Yang Pan, Wei Xiong*. Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice. Molecular Brain, 14, 41 (2021)
Jin Ye#, Guichang Zou#, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li*, Wei Xiong*, and Chao Wang*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications, (2021), 12:297
Jin Shiyun., Cao Qi., Yang Fanghan., Zhu Hongying., Xu Su., Chen Qi., Wang Ziyi., Lin Yuhong., Cinar Resat., Pawlosky Robert J., Zhang Ye., Xiong Wei., Gao Bin., Koob George F., Lovinger David M., Zhang Li*. Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication. Nature Metabolism, 3(3), 337-351 (2021). (封面文章)
Shuangshuang Tian, Zhuanghao Hou, Xin Zuo, Wei Xiong, Guangming Huang*. Automatic Registration of the Mass Spectrometry Imaging Data of Sagittal Brain Slices to the Reference Atlas. J Am Soc Mass Spectrom, 32(7): 1789-1797 (2021)
Xudong Zhu#, Weiyan Shen#, Zhu Liu, Shihao Sheng, Wei Xiong, Ruikun He, Xuguang Zhang*, Likun Ma*, Zhenyu Ju*. Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice. Front Cell Dev Biol, 8: 626011 (2021)
2020
Guichang Zou#, Xin Zuo#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu and Wei Xiong*. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 30(12), 4209-4219 (2020)
Lei Yao, Chengyuan Liu, Ning Wang, Feng Du, Sijia Fan, Yujun Guo, Li Zhang, Yang Pan, Wei Xiong*. Cholesterol regulates cannabinoid analgesia through glycine receptors. Neuropharmacology, 15; 177:108242, (2020)
Lei Yao, Marta Wells, Xiongwu Wu, Yan Xu, Li Zhang*, Wei Xiong*. Membrane cholesterol dependence of cannabinoid modulation of glycine receptor. FASEB J, 34: 10920-10930 (2020)
Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, and Wei Xiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. J Biol Chem, 295: 138-145 (2020)
Shijin Xu#, Yan Xu#, Xueying Cheng#, Cheng Huang, Yonglu Pan, Shiyun Jin, Wei Xiong, Li Zhang, Shufang He, Ye Zhang. Inhibition of DRG-TRPV1 upregulation in myocardial ischemia contributes to exogenous cardioprotection. Journal of Molecular and Cellular Cardiology, 138: 175-184 (2020)
Qianjin Liu, Ling-Yan Su, Chunli Sun, Lijin Jiao, Ying Miao, Min Xu, Rongcan Luo, Xin Zuo, Rongbin Zhou, Ping Zheng, Wei Xiong, Tian Xue, Yong-Gang Yao. Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation, Redox Biology, 34, (2020)
2019
Xiaoqun Wang#, Yiwen Hou#, Zhuanghao Hou, Wei Xiong*, Guangming Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization. Analytical chemistry 91, 2719-2726 (2019)
Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang and Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience , 19:634-646 (2019)
Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang, Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang, Zhenkun Lin, Yongmei Lv, Wei Xiong*, Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical chemistry 91, 6616-6623 (2019)
Cheng Huang#, Jie Wang#, Ning Wang, Feng Du, Wei Xiong, Junchao Qian, Kai Zhong, Aoling Cai, Shijin Xu, Jun Huang, Xueying Cheng, Shufang He*, Ye Zhang*. Effect of myocardial ischemic preconditioning on ischemia-reperfusion stimulation-induced activation in rat thoracic spinal cord with functional MRI.International Journal of Cardiology, 285: 59-64 (2019)
Mengyun Dou#, Zhenxiao Ma#, Xueying Cheng, Guichang Zou, Yan Xu, Cheng Huang, Wei Xiong, Shufang He*, YeZhang*. Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat. British Journal of Anaesthesia, 123(4): 439-449 (2019)
2018
Hongying Zhu#; Ning Wang#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei
Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li;
Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*;Wei Xiong*. Moderate UV exposure
enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the
brain.
Cell, 173(7): 1716-1727 (2018)
(2018年度中国生命科学十大进展)
Jieping Lu#; Sijia Fan#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang;Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.Neuropharmacology, 133: 224-232 (2018)
2017
Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang, Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry.PNAS , 114: 2586~2591 (2017)
2014
Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature Neuroscience, 17: 232-239 (2014)
Luis G Aguayo*, Patricio Castro, Trinidad Mariqueo, Braulio Muñoz, Wei Xiong, Li Zhang, David M Lovinger & Gregg E Homanics*. Altered Sedative Effects of Ethanol in Mice with α1 Glycine Receptor Subunits that are Insensitive to Gβγ Modulation. Neuropsychopharmacology, 39: 2538–2548 (2014)
2012
Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targetingα3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
2011
Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology,7: 296-303(2011)
中文期刊
徐延，邹桂昌，左欣，熊伟*。维生素C对不同亚型甘氨酸受体功能的影响。 中国药理学通报，37(2):187-191 (2021)
朱洪影，易林，汪子怡，熊伟*。单细胞代谢组学分析技术研究进展。 中国科学技术大学学报，48(10): 842-852 (2018)
郭薇薇，姚磊，熊伟*。大麻镇痛机制。中国疼痛医学杂志, 8: 561~566（2015）
毕丹蕾，文朗，熊伟，申勇*。阿尔茨海默病的可能药物靶点和临床治疗研究进展。 中国药理学与毒理学杂志, 4: 507~536（2015）
